Angelo Colari and the Hotel Europe, 1908, by Frank Lewis, 1976. As mentioned in his bio, Frank painted the mural on the side of the Maritime Museum in 1986, and he painted the hoardings at the old Vancouver Court house at some point as well. More about the drawing from Gastown.org:

Angelo Colari built the Europe on this triangular-shaped lot near the steamship docks that used to be located at the foot of Columbia and Carrall Streets. Colari was born in Italy in 1861 and immigrated to British Columbia in 1882 when he was 21 years old.  He spent four years in Victoria before coming to Vancouver in 1886.

This drawing was the front cover of yesterday’s historical map, a pre-Expo96 Downtown Historical Association Historical Trek.

Rand and Edgar Mural (Maritime Museum Mural) by Frank Lewis, 1986.

“Through a series of interconnected images, this mural tells of the people and ships that played a vital role in shaping the history and culture of Vancouver. Two centuries of activity are traced in time from left to right.” (information sheet from the Maritime Museum) In the upper left, the “Lions” represent the geographic outlook of Vancouver. The activity on the sea is represented by images of First Nations peoples and their canoes and Captain George Vancouver and his ship Discovery along with Valdes and Galiano and their ships Sutil and Mexicana from 1792.The image also shows Captain GH Richards who surveyed the area and his ship Plumber as well as the Beaver, the first steamship on the coast, a Hudson Bay Company supply vessel, along with others. In the diamond in the centre of the image is the Empress of Japan and its famous dragon figurehead which is in the Museum’s collection. Modern freighters and luxury steamers complete this section of the picture. The Lions Gate Bridge, built in 1939, is depicted, as is the St Roch, the RCMP patrol vessel that worked the North-West Passage in the early 1940s, which is housed in the Maritime Museum. Also shown are the Ivanhoe and the Master, wood-hulled tugs from the early 20th century. The harbour is depicted by Canada Place with its cruise ship facility and the Saskatchewan Grain Pool elevator and a Japanese freighter. The people who work in the harbour are also shown, identifiably Joe Fortes, the legendary English Bay lifeguard. The mural was created for the Vancouver Centennial in 1986. It is a project of the Vancouver Legacies Programme in cooperation with the Vancouver Maritime Museum and a gift to the city from the firm of Rand and Edgar, Barristers and Solicitors. [source]